Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
Data(s) |
01/01/2005
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Resumo |
Dendritic cells (DCs) regulate various aspects of innate immunity, including natural killer (NK) cell function. Here we define the mechanisms involved in DC - NK cell interactions during viral infection. NK cells were efficiently activated by murine cytomegalovirus ( MCMV) - infected CD11b(+) DCs. NK cell cytotoxicity required interferon-alpha and interactions between the NKG2D activating receptor and NKG2D ligand, whereas the production of interferon-gamma by NK cells relied mainly on DC-derived interleukin 18. Although Toll-like receptor 9 contributes to antiviral immunity, we found that signaling pathways independent of Toll-like receptor 9 were important in generating immune responses to MCMV, including the production of interferon-alpha and the induction of NK cell cytotoxicity. Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Nature Publishing Group |
Palavras-Chave | #Immunology #Murine Cytomegalovirus-infection #Colony-stimulating Factor #Ifn-alpha-beta #Nk Cells #Nkg2d Receptor #In-vivo #Viral-infections #Interferon-alpha/beta #Cytokine Responses #Tumor-immunity #C1 #320202 Cellular Immunology #730101 Infectious diseases |
Tipo |
Journal Article |