Lectin-induced haemocyte inactivation in insects
Contribuinte(s) |
D. L. Denlinger S. E. Reynolds |
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Data(s) |
01/01/2004
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Resumo |
Most multimeric lectins are adhesion molecules, promoting attachment and spreading on surface glycodeterminants. In addition, some lectins have counter-adhesion properties, detaching already spread cells which then acquire round or spindle-formed cell shapes. Since lectin-mediated adhesion and detachment is observed in haemocyte-like Drosophila cells, which have haemomucin as the major lectin-binding glycoprotein, the two opposite cell behaviours may be the result of lectin-mediated receptor rearrangements on the cell surface. To investigate oligomeric lectins as a possible extracellular driving force affecting cell shape changes, we examined lectin-mediated reactions in lepidopteran haemocytes after cytochalasin D-treatment and observed that while cell-spreading was dependent on F-actin, lectin-uptake was less dependent on F-actin. We propose a model of cell shape changes involving a dynamic balance between adhesion and uptake reactions. (C) 2004 Elsevier Ltd. All rights reserved. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Pergamon-elsevier Science Ltd |
Palavras-Chave | #Physiology #Lectin #Adhesion #Counter-adhesion #Endocytosis #Actin-cytoskeleton #Cytochalasin D #Glycodeterminants #Secondary Metabolites #Galleria-mellonella #Actin #Cells #Thrombospondin-1 #Protein #Surface #Cytoskeleton #Endocytosis #Activation #Entomology #C1 #270105 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) #780105 Biological sciences |
Tipo |
Journal Article |