Mast cells in human periodontal disease
Contribuinte(s) |
Mark Herzberg |
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Data(s) |
01/01/2004
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Resumo |
Recently, mast cells have been shown to produce cytokines which can direct the development of T-cell subsets. The aim of the present study was to determine the relationship between mast cells and the Th1/Th2 response in human periodontal disease. Tryptase+ mast cell numbers were decreased in chronic periodontitis tissues compared with healthy/gingivitis lesions. Lower numbers of c-kit+ cells, which remained constant regardless of clinical status, indicate that there may be no increased migration of mast cells into periodontal disease lesions. While there were no differences in IgG2+ or IgG4+ cell numbers in healthy/gingivitis samples, there was an increase in IgG4+ cells compared with IgG2+ cells in periodontitis lesions, numbers increasing with disease severity. This suggests a predominance of Th2 cells in periodontitis, although mast cells may not be the source of Th2-inducing cytokines. |
Identificador | |
Idioma(s) |
eng |
Publicador |
American Assoc for Dental Research |
Palavras-Chave | #Dentistry, Oral Surgery & Medicine #Mast Cells #Periodontal Disease #Immunohistology #Interferon-gamma #T-lymphocytes #Interleukin-3 #Expression #Growth #C1 #320899 Dentistry not elsewhere classified #730112 Oro-dental and disorders |
Tipo |
Journal Article |