CSF-1 as a regulator of macrophage activation and immune responses
Contribuinte(s) |
Krotkiewski Hubert; Gorski Andrzej |
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Data(s) |
01/01/2003
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Resumo |
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony-stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarize our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wydawnictwo Ossolineum |
Palavras-Chave | #Immunology #Csf-1 #Macrophage #Lipopolysaccharide #Toll-like Receptors #Inflammation #Colony-stimulating Factor #Tumor-necrosis-factor #Factor-i Receptor #Human-immunodeficiency-virus #Growth-factor Csf-1 #P40 Gene Promoter #Plasminogen-activator #Human Monocytes #Granulocyte-macrophage #C1 #320202 Cellular Immunology #730102 Immune system and allergy |
Tipo |
Journal Article |