When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study.
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01/06/2016
31/12/1969
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Resumo |
OBJECTIVE To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). DESIGN Prospective studies of HIV-positive individuals in Europe and the USA in the HIV-CAUSAL Collaboration and The Center for AIDS Research Network of Integrated Clinical Systems. METHODS Antiretroviral-naive individuals who initiated ART and became virologically suppressed within 12 months were followed from the date of suppression. We compared 3 CD4 cell count and HIV-RNA monitoring strategies: once every (1) 3 ± 1 months, (2) 6 ± 1 months, and (3) 9-12 ± 1 months. We used inverse-probability weighted models to compare these strategies with respect to clinical, immunologic, and virologic outcomes. RESULTS In 39,029 eligible individuals, there were 265 deaths and 690 AIDS-defining illnesses or deaths. Compared with the 3-month strategy, the mortality hazard ratios (95% CIs) were 0.86 (0.42 to 1.78) for the 6 months and 0.82 (0.46 to 1.47) for the 9-12 month strategy. The respective 18-month risk ratios (95% CIs) of virologic failure (RNA >200) were 0.74 (0.46 to 1.19) and 2.35 (1.56 to 3.54) and 18-month mean CD4 differences (95% CIs) were -5.3 (-18.6 to 7.9) and -31.7 (-52.0 to -11.3). The estimates for the 2-year risk of AIDS-defining illness or death were similar across strategies. CONCLUSIONS Our findings suggest that monitoring frequency of virologically suppressed individuals can be decreased from every 3 months to every 6, 9, or 12 months with respect to clinical outcomes. Because effects of different monitoring strategies could take years to materialize, longer follow-up is needed to fully evaluate this question. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/83632/1/Caniglia%20JAcquirImmuneDeficSyndr%202016.pdf Caniglia, Ellen C; Sabin, Caroline; Robins, James M; Logan, Roger; Cain, Lauren E; Abgrall, Sophie; Mugavero, Michael J; Hernandez-Diaz, Sonia; Meyer, Laurence; Seng, Remonie; Drozd, Daniel R; Seage, George R; Bonnet, Fabrice; Dabis, Francois; Moore, Richard R; Reiss, Peter; van Sighem, Ard; Mathews, William C; Del Amo, Julia; Moreno, Santiago; ... (2016). When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study. Journal of acquired immune deficiency syndromes JAIDS, 72(2), pp. 214-221. Lippincott Williams & Wilkins 10.1097/QAI.0000000000000956 <http://dx.doi.org/10.1097/QAI.0000000000000956> doi:10.7892/boris.83632 info:doi:10.1097/QAI.0000000000000956 info:pmid:26895294 urn:issn:0894-9255 |
Idioma(s) |
eng |
Publicador |
Lippincott Williams & Wilkins |
Relação |
http://boris.unibe.ch/83632/ |
Direitos |
info:eu-repo/semantics/embargoedAccess |
Fonte |
Caniglia, Ellen C; Sabin, Caroline; Robins, James M; Logan, Roger; Cain, Lauren E; Abgrall, Sophie; Mugavero, Michael J; Hernandez-Diaz, Sonia; Meyer, Laurence; Seng, Remonie; Drozd, Daniel R; Seage, George R; Bonnet, Fabrice; Dabis, Francois; Moore, Richard R; Reiss, Peter; van Sighem, Ard; Mathews, William C; Del Amo, Julia; Moreno, Santiago; ... (2016). When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study. Journal of acquired immune deficiency syndromes JAIDS, 72(2), pp. 214-221. Lippincott Williams & Wilkins 10.1097/QAI.0000000000000956 <http://dx.doi.org/10.1097/QAI.0000000000000956> |
Palavras-Chave | #610 Medicine & health #360 Social problems & social services |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |