T Cell Motility as Modulator of Interactions with Dendritic Cells
Data(s) |
2015
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Resumo |
It is well established that the balance of costimulatory and inhibitory signals during interactions with dendritic cells (DCs) determines T cell transition from a naïve to an activated or tolerant/anergic status. Although many of these molecular interactions are well reproduced in reductionist in vitro assays, the highly dynamic motility of naïve T cells in lymphoid tissue acts as an additional lever to fine-tune their activation threshold. T cell detachment from DCs providing suboptimal stimulation allows them to search for DCs with higher levels of stimulatory signals, while storing a transient memory of short encounters. In turn, adhesion of weakly reactive T cells to DCs presenting peptides presented on major histocompatibility complex with low affinity is prevented by lipid mediators. Finally, controlled recruitment of CD8(+) T cells to cognate DC-CD4(+) T cell clusters shapes memory T cell formation and the quality of the immune response. Dynamic physiological lymphocyte motility therefore constitutes a mechanism to mitigate low avidity T cell activation and to improve the search for "optimal" DCs, while contributing to peripheral tolerance induction in the absence of inflammation. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/77341/1/fimmu-06-00559.pdf Stein, Jens Volker (2015). T Cell Motility as Modulator of Interactions with Dendritic Cells. Frontiers in immunology, 6, p. 559. Frontiers Research Foundation 10.3389/fimmu.2015.00559 <http://dx.doi.org/10.3389/fimmu.2015.00559> doi:10.7892/boris.77341 info:doi:10.3389/fimmu.2015.00559 info:pmid:26579132 urn:issn:1664-3224 |
Idioma(s) |
eng |
Publicador |
Frontiers Research Foundation |
Relação |
http://boris.unibe.ch/77341/ |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Stein, Jens Volker (2015). T Cell Motility as Modulator of Interactions with Dendritic Cells. Frontiers in immunology, 6, p. 559. Frontiers Research Foundation 10.3389/fimmu.2015.00559 <http://dx.doi.org/10.3389/fimmu.2015.00559> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |