T Cell Motility as Modulator of Interactions with Dendritic Cells


Autoria(s): Stein, Jens Volker
Data(s)

2015

Resumo

It is well established that the balance of costimulatory and inhibitory signals during interactions with dendritic cells (DCs) determines T cell transition from a naïve to an activated or tolerant/anergic status. Although many of these molecular interactions are well reproduced in reductionist in vitro assays, the highly dynamic motility of naïve T cells in lymphoid tissue acts as an additional lever to fine-tune their activation threshold. T cell detachment from DCs providing suboptimal stimulation allows them to search for DCs with higher levels of stimulatory signals, while storing a transient memory of short encounters. In turn, adhesion of weakly reactive T cells to DCs presenting peptides presented on major histocompatibility complex with low affinity is prevented by lipid mediators. Finally, controlled recruitment of CD8(+) T cells to cognate DC-CD4(+) T cell clusters shapes memory T cell formation and the quality of the immune response. Dynamic physiological lymphocyte motility therefore constitutes a mechanism to mitigate low avidity T cell activation and to improve the search for "optimal" DCs, while contributing to peripheral tolerance induction in the absence of inflammation.

Formato

application/pdf

Identificador

http://boris.unibe.ch/77341/1/fimmu-06-00559.pdf

Stein, Jens Volker (2015). T Cell Motility as Modulator of Interactions with Dendritic Cells. Frontiers in immunology, 6, p. 559. Frontiers Research Foundation 10.3389/fimmu.2015.00559 <http://dx.doi.org/10.3389/fimmu.2015.00559>

doi:10.7892/boris.77341

info:doi:10.3389/fimmu.2015.00559

info:pmid:26579132

urn:issn:1664-3224

Idioma(s)

eng

Publicador

Frontiers Research Foundation

Relação

http://boris.unibe.ch/77341/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Stein, Jens Volker (2015). T Cell Motility as Modulator of Interactions with Dendritic Cells. Frontiers in immunology, 6, p. 559. Frontiers Research Foundation 10.3389/fimmu.2015.00559 <http://dx.doi.org/10.3389/fimmu.2015.00559>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed