Functional and anatomical outcome of eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab following an exit strategy regimen.


Autoria(s): Menke, Marcel N; Zinkernagel, Martin S; Ebneter, Andreas; Wolf, Sebastian
Data(s)

29/04/2014

Resumo

AIMS To assess the functional and morphological outcome of eyes with neovascular AMD treated with intravitreal ranbizumab following an exit strategy treatment regime. METHODS The Bern treatment regime for neovascular AMD has a fixed injection schedule, even in the non-active stage of the disease. The regimen has been adapted from the PIER study treatment protocol. Eyes with non-active AMD will receive 4 injections in the first year, and 2 injections in the second year of follow-up before treatment stops. Patients that received ranibizumab for treatment and reached the exit criteria were identified, and charts were reviewed to assess functional and morphological outcome. RESULTS Only 2.6% of all patients (15 out of 575 patients) reached the exit criteria. Mean change in best corrected ETDRS visual acuity (VA) was 4.5±16.9 letters when comparing baseline VA to 4 weeks after the last injection (p=0.32). OCT mean foveal thickness was significantly thinner after last treatment (247.9±43.0 µm) compared to baseline (332.5±83.1 µm, p=0.002). The mean total number of ranibizumab injections was 15.6±8.0, and the mean total treatment period was 40.9±18.3 months. Twenty percent of eyes had geographic atrophy present at baseline versus 46.6% at the end of treatment. CONCLUSIONS Even with a fixed treatment regime and a defined treatment exit strategy, only a small percentage of patients reach exit criteria. Retinal thickness has been significantly reduced by repeated intravitreal ranibizumab injections, and geographic atrophy became more frequent.

Formato

application/pdf

Identificador

http://boris.unibe.ch/53508/1/1197.full.pdf

Menke, Marcel N; Zinkernagel, Martin S; Ebneter, Andreas; Wolf, Sebastian (2014). Functional and anatomical outcome of eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab following an exit strategy regimen. British journal of ophthalmology, 98(9), pp. 1197-1200. BMJ Publishing Group 10.1136/bjophthalmol-2013-304775 <http://dx.doi.org/10.1136/bjophthalmol-2013-304775>

doi:10.7892/boris.53508

info:doi:10.1136/bjophthalmol-2013-304775

info:pmid:24782472

urn:issn:0007-1161

Idioma(s)

eng

Publicador

BMJ Publishing Group

Relação

http://boris.unibe.ch/53508/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Menke, Marcel N; Zinkernagel, Martin S; Ebneter, Andreas; Wolf, Sebastian (2014). Functional and anatomical outcome of eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab following an exit strategy regimen. British journal of ophthalmology, 98(9), pp. 1197-1200. BMJ Publishing Group 10.1136/bjophthalmol-2013-304775 <http://dx.doi.org/10.1136/bjophthalmol-2013-304775>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed