Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory.
Data(s) |
04/01/2006
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Resumo |
Integrins comprise a large family of cell adhesion receptors that mediate diverse biological events through cell-cell and cell-extracellular matrix interactions. Recent studies have shown that several integrins are localized to synapses with suggested roles in synaptic plasticity and memory formation. We generated a postnatal forebrain and excitatory neuron-specific knock-out of beta1-integrin in the mouse. Electrophysiological studies demonstrated that these mutants have impaired synaptic transmission through AMPA receptors and diminished NMDA receptor-dependent long-term potentiation. Despite the impairment in hippocampal synaptic transmission, the mutants displayed normal hippocampal-dependent spatial and contextual memory but were impaired in a hippocampal-dependent, nonmatching-to-place working memory task. These phenotypes parallel those observed in animals carrying knock-outs of the GluR1 (glutamate receptor subunit 1) subunit of the AMPA receptor. These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory. |
Identificador |
http://digitalcommons.library.tmc.edu/baylor_docs/7 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2408376 |
Publicador |
DigitalCommons@The Texas Medical Center |
Fonte |
Baylor Faculty Publications |
Palavras-Chave | #Animals #Antigens #CD29 #Hippocampus #Memory #Mice #Mice #Inbred C57BL #Mice #Knockout #Neuronal Plasticity #Receptors #AMPA #Synaptic Transmission #Antigens, CD29 #Mice, Inbred C57BL #Mice, Knockout #Receptors, AMPA #Medicine and Health Sciences |
Tipo |
text |