Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases
Data(s) |
01/07/2014
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Resumo |
A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients with anxiety associated with life-threatening diseases. Treatment included drug-free psychotherapy sessions supplemented by two LSD-assisted psychotherapy sessions 2 to 3 weeks apart. The participants received either 200 μg of LSD (n = 8) or 20 μg of LSD with an open-label crossover to 200 μg of LSD after the initial blinded treatment was unmasked (n = 4). At the 2-month follow-up, positive trends were found via the State-Trait Anxiety Inventory (STAI) in reductions in trait anxiety (p = 0.033) with an effect size of 1.1, and state anxiety was significantly reduced (p = 0.021) with an effect size of 1.2, with no acute or chronic adverse effects persisting beyond 1 day after treatment or treatment-related serious adverse events. STAI reductions were sustained for 12 months. These results indicate that when administered safely in a methodologically rigorous medically supervised psychotherapeutic setting, LSD can reduce anxiety, suggesting that larger controlled studies are warranted.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/46004/1/Safety_and_Efficacy_of_Lysergic_Acid.99925.pdf Gasser, Peter; Holstein, Dominique Hans; Michel, Yvonne; Doblin, Rick; Yazar-Klosinski, Berra; Passie, Torsten; Brenneisen, Rudolf Max (2014). Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases. Journal of nervous and mental disease, 202(7), pp. 513-520. Lippincott Williams & Wilkins 10.1097/NMD.0000000000000113 <http://dx.doi.org/10.1097/NMD.0000000000000113> doi:10.7892/boris.46004 info:doi:10.1097/NMD.0000000000000113 info:pmid:24594678 urn:issn:0022-3018 |
Idioma(s) |
eng |
Publicador |
Lippincott Williams & Wilkins |
Relação |
http://boris.unibe.ch/46004/ |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Gasser, Peter; Holstein, Dominique Hans; Michel, Yvonne; Doblin, Rick; Yazar-Klosinski, Berra; Passie, Torsten; Brenneisen, Rudolf Max (2014). Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases. Journal of nervous and mental disease, 202(7), pp. 513-520. Lippincott Williams & Wilkins 10.1097/NMD.0000000000000113 <http://dx.doi.org/10.1097/NMD.0000000000000113> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |