Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men.


Autoria(s): Lecoultre, Virgile; Carrel, Guillaume; Egli, Léonie; Binnert, Christophe; Boss, Andreas; Macmillan, Erin; Kreis, Roland; Boesch, Chris; Darimont, Christian; Tappy, Luc
Data(s)

01/02/2014

Resumo

BACKGROUND Epidemiologic and experimental data have suggested that chlorogenic acid, which is a polyphenol contained in green coffee beans, prevents diet-induced hepatic steatosis and insulin resistance. OBJECTIVE We assessed whether the consumption of chlorogenic acid-rich coffee attenuates the effects of short-term fructose overfeeding, dietary conditions known to increase intrahepatocellular lipids (IHCLs), and blood triglyceride concentrations and to decrease hepatic insulin sensitivity in healthy humans. DESIGN Effects of 3 different coffees were assessed in 10 healthy volunteers in a randomized, controlled, crossover trial. IHCLs, hepatic glucose production (HGP) (by 6,6-d2 glucose dilution), and fasting lipid oxidation were measured after 14 d of consumption of caffeinated coffee high in chlorogenic acid (C-HCA), decaffeinated coffee high in chlorogenic acid, or decaffeinated coffee with regular amounts of chlorogenic acid (D-RCA); during the last 6 d of the study, the weight-maintenance diet of subjects was supplemented with 4 g fructose · kg(-1) · d(-1) (total energy intake ± SD: 143 ± 1% of weight-maintenance requirements). All participants were also studied without coffee supplementation, either with 4 g fructose · kg(-1) · d(-1) (high fructose only) or without high fructose (control). RESULTS Compared with the control diet, the high-fructose diet significantly increased IHCLs by 102 ± 36% and HGP by 16 ± 3% and decreased fasting lipid oxidation by 100 ± 29% (all P < 0.05). All 3 coffees significantly decreased HGP. Fasting lipid oxidation increased with C-HCA and D-RCA (P < 0.05). None of the 3 coffees significantly altered IHCLs. CONCLUSIONS Coffee consumption attenuates hepatic insulin resistance but not the increase of IHCLs induced by fructose overfeeding. This effect does not appear to be mediated by differences in the caffeine or chlorogenic acid content. This trial was registered at clinicaltrials.gov as NCT00827450.

Formato

application/pdf

Identificador

http://boris.unibe.ch/43871/1/268.full.pdf

Lecoultre, Virgile; Carrel, Guillaume; Egli, Léonie; Binnert, Christophe; Boss, Andreas; Macmillan, Erin; Kreis, Roland; Boesch, Chris; Darimont, Christian; Tappy, Luc (2014). Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men. American journal of clinical nutrition, 99(2), pp. 268-275. American Society for Nutrition, Inc. 10.3945/ajcn.113.069526 <http://dx.doi.org/10.3945/ajcn.113.069526>

doi:10.7892/boris.43871

info:doi:10.3945/ajcn.113.069526

info:pmid:24257718

urn:issn:0002-9165

Idioma(s)

eng

Publicador

American Society for Nutrition, Inc.

Relação

http://boris.unibe.ch/43871/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Lecoultre, Virgile; Carrel, Guillaume; Egli, Léonie; Binnert, Christophe; Boss, Andreas; Macmillan, Erin; Kreis, Roland; Boesch, Chris; Darimont, Christian; Tappy, Luc (2014). Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men. American journal of clinical nutrition, 99(2), pp. 268-275. American Society for Nutrition, Inc. 10.3945/ajcn.113.069526 <http://dx.doi.org/10.3945/ajcn.113.069526>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed