Case and partnership reproduction numbers for a curable sexually transmitted infection


Autoria(s): Heijne, Janneke C. M.; Herzog, Sereina A.; Althaus, Christian L.; Low, Nicola; Kretzschmar, Mirjam
Data(s)

21/08/2013

Resumo

Sexually transmitted infections (STIs) are, by definition, transmitted between sexual partners. For curable STIs an infected index case can potentially re-infect the same partner multiple times. Thus, R0, the average number of secondary infections one typical infected individual will produce during his or her infectious period is not necessarily the same as the average number of secondary cases (infected persons). Here we introduce the new concept of the case reproduction number (Rc). In addition, we define the partnership reproduction number (Rp) as the average number of secondary partnerships consisting of two infected individuals one typical infected individual will produce over his or her infectious lifetime. Rp takes into account clearance and re-infection within partnerships, which results in a prolongation of the duration of the infectious period. The two new reproduction numbers were derived for a deterministic pair model with serial monogamous partnerships using infection parameters for Chlamydia trachomatis, an example of a curable STI. We showed that re-infection within partnerships means that curable STIs can be sustained endemically even when the average number of secondary cases a person produces during his or her infectious period is below one.

Formato

application/pdf

application/pdf

Identificador

http://boris.unibe.ch/41855/1/Heijne%20JTheorBiol%202013.pdf

http://boris.unibe.ch/41855/7/Heijne%20JTheorBiol%202013_post-print.pdf

Heijne, Janneke C. M.; Herzog, Sereina A.; Althaus, Christian L.; Low, Nicola; Kretzschmar, Mirjam (2013). Case and partnership reproduction numbers for a curable sexually transmitted infection. JOURNAL OF THEORETICAL BIOLOGY, 331, pp. 38-47. Elsevier 10.1016/j.jtbi.2013.04.010 <http://dx.doi.org/10.1016/j.jtbi.2013.04.010>

doi:10.7892/boris.41855

info:doi:10.1016/j.jtbi.2013.04.010

info:pmid:23608632

urn:issn:0022-5193

Idioma(s)

eng

Publicador

Elsevier

Relação

http://boris.unibe.ch/41855/

Direitos

info:eu-repo/semantics/restrictedAccess

info:eu-repo/semantics/openAccess

Fonte

Heijne, Janneke C. M.; Herzog, Sereina A.; Althaus, Christian L.; Low, Nicola; Kretzschmar, Mirjam (2013). Case and partnership reproduction numbers for a curable sexually transmitted infection. JOURNAL OF THEORETICAL BIOLOGY, 331, pp. 38-47. Elsevier 10.1016/j.jtbi.2013.04.010 <http://dx.doi.org/10.1016/j.jtbi.2013.04.010>

Palavras-Chave #610 Medicine & health #360 Social problems & social services
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed