Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents
| Data(s) |
17/01/2008
17/01/2008
2002
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|---|---|
| Resumo |
The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized isoxazole-based libraries comprising of 32, 96 and 45 compounds each have been synthesized in parallel format using Baylis Hillman reaction, Michael addition, reductive amination and alkylation reactions. With an objective of lead generation all the three libraries were evaluated for their antithrombin activity in vivo. |
| Formato |
122786 bytes 53757 bytes application/pdf application/pdf |
| Identificador |
Bioorg. Med. Chem. Lett. 12, 1905-1908, Bioorganic & Medicinal Chemistry Letters 12 (2002) 3349 |
| Idioma(s) |
en |
| Relação |
CDRI Communication no. 6071 |
| Tipo |
Article |
