Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway
Data(s) |
2003
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Resumo |
In experimental bacterial meningitis, matrix metalloproteinases (MMPs) and reactive oxygen species (ROS) contribute to brain damage. MMP-9 increases in cerebrospinal fluid (CSF) during bacterial meningitis and is associated with the brain damage that is a consequence of the disease. This study assesses the origin of MMP-9 in bacterial meningitis and how ROS modulate its activity. Rat brain-slice cultures and rat polymorphonuclear cells (PMNs) that had been challenged with capsule-deficient heat-inactivated Streptococcus pneumoniae R6 (hiR6) released MMP-9. Coincubation with either catalase, with the myeloperoxidase inhibitor azide, or with the hypochlorous acid scavenger methionine almost completely prevented activation, but not the release, of MMP-9, in supernatants of human PMNs stimulated with hiR6. Thus, in bacterial meningitis, both brain-resident cells and invading PMNs may act as sources of MMP-9, and stimulated PMNs may activate MMP-9 via an ROS-dependent pathway. MMP-9 activation by ROS may represent a target for therapeutic intervention in bacterial meningitis. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/23685/1/J%20Infect%20Dis.-2003-Meli-1411-5.pdf Meli, Damian N.; Christen, Stephan; Leib, Stephen L. (2003). Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. Journal of infectious diseases, 187(9), pp. 1411-1415. Cary, N.C.: Oxford University Press 10.1086/374644 <http://dx.doi.org/10.1086/374644> doi:10.7892/boris.23685 info:doi:10.1086/374644 info:pmid:12717622 urn:issn:0022-1899 urn:isbn:12717622 |
Idioma(s) |
eng |
Publicador |
Oxford University Press |
Relação |
http://boris.unibe.ch/23685/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Meli, Damian N.; Christen, Stephan; Leib, Stephen L. (2003). Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. Journal of infectious diseases, 187(9), pp. 1411-1415. Cary, N.C.: Oxford University Press 10.1086/374644 <http://dx.doi.org/10.1086/374644> |
Palavras-Chave | #570 Life sciences; biology #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |