Maternal tobacco smoking and decreased leukocytes, including dendritic cells, in neonates


Autoria(s): Pachlopnik Schmid, JM; Kuehni, CE; Strippoli, MP; Roiha, HL; Pavlovic, R; Latzin, P; Gallati, S; Kraemer, R; Dahinden, C; Frey, U; Swiss, Pediatric Respiratory Research Group
Data(s)

2007

Resumo

Maternal smoking in pregnancy is associated with respiratory diseases in the offspring, possibly due to prenatal influences on the developing immune system. We investigated whether maternal smoking in pregnancy was associated with cord blood leukocyte numbers, including precursor dendritic cells, adjusting for concomitant factors. In a prospective healthy birth cohort study, total leukocyte counts were reduced in neonates of smoking mothers [10.7 (8.4-13.0), n=14] compared with nonexposed infants [14.7 (13.7-15.7), n=74, p=0.002] [geometric mean cells x 10(3)/microL (95% confidence interval)]. All leukocyte subsets were decreased, most prominently segmented neutrophils [4.3 (2.8-5.7) versus 6.2 (5.5-6.8), p=0.021], lymphocytes [3.8 (2.9-4.8) versus 5.0 (4.5-5.6), p=0.036], and myeloid precursor dendritic cells [12.7 cells/microL (9.1-17.8) versus 18.3 (15.8-21.2), p=0.055]. These differences persisted after adjustment for possible confounders. Predictors of myeloid precursor dendritic cell numbers in multivariable models were maternal smoking (-5.1 cells/microL, p=0.042), age (-0.5 cells/microL/y, p=0.035), and, marginally, asthma (+8.1 cells/microL, p=0.075). The decrease of all leukocytes in neonates of smoking mothers could be clinically significant and suggests a decreased cell production, increased peripheral recruitment, or retention in bone marrow. Given the importance of dendritic cells in early immune responses, their decrease might reflect an impact of maternal smoking on the developing fetal immune system.

Formato

application/pdf

Identificador

http://boris.unibe.ch/22044/1/Pachlopnik%20PediatrRes%202007.pdf

Pachlopnik Schmid, JM; Kuehni, CE; Strippoli, MP; Roiha, HL; Pavlovic, R; Latzin, P; Gallati, S; Kraemer, R; Dahinden, C; Frey, U; Swiss, Pediatric Respiratory Research Group (2007). Maternal tobacco smoking and decreased leukocytes, including dendritic cells, in neonates. Pediatric research, 61(4), pp. 462-6. New York, N.Y.: Nature Publishing Group 10.1203/pdr.0b013e3180332d02 <http://dx.doi.org/10.1203/pdr.0b013e3180332d02>

doi:10.7892/boris.22044

info:doi:10.1203/pdr.0b013e3180332d02

info:pmid:17515872

urn:issn:0031-3998

urn:isbn:17515872

Idioma(s)

eng

Publicador

Nature Publishing Group

Relação

http://boris.unibe.ch/22044/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Pachlopnik Schmid, JM; Kuehni, CE; Strippoli, MP; Roiha, HL; Pavlovic, R; Latzin, P; Gallati, S; Kraemer, R; Dahinden, C; Frey, U; Swiss, Pediatric Respiratory Research Group (2007). Maternal tobacco smoking and decreased leukocytes, including dendritic cells, in neonates. Pediatric research, 61(4), pp. 462-6. New York, N.Y.: Nature Publishing Group 10.1203/pdr.0b013e3180332d02 <http://dx.doi.org/10.1203/pdr.0b013e3180332d02>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

NonPeerReviewed