Spatial Learning and Stress Response of Male Rats Prenatally Exposed to Dexamethasone
Data(s) |
01/01/2010
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Resumo |
Dexamethasone is routinely administered to women at risk for a preterm birth in order to enhance fetal lung development and reduce uterine contractions. Research has demonstrated possible behavioral abnormalities in adulthood as a result of dexamethasone treatment. Using nonlinear mixed effects modeling, this study found thatprenatal dexamethasone treatment impaired spatial learning and memory of adult male Sprague-Dawley rats. Prenatal dexamethasone treatment also led to more anxiety related behaviors on Elevated Plus Maze testing 1.5 hours after a stress challenge. Because theassumptions underlying the independent samples t-test were violated, the randomization test was used to compare groups on the Elevated Plus Maze. |
Formato |
application/pdf |
Identificador |
http://digitalcommons.bucknell.edu/masters_theses/17 http://digitalcommons.bucknell.edu/cgi/viewcontent.cgi?article=1016&context=masters_theses |
Publicador |
Bucknell Digital Commons |
Fonte |
Master’s Theses |
Palavras-Chave | #Prenatal Dexamethasone #Glucocorticoids #Stress Challenge #Nonlinear Mixed Effects Modeling #Randomization Test #Medical Sciences |
Tipo |
text |