Bioactivity of extracts from extremophile microalgae Coccomyxa sp. on chloride cells in operculum tissue of Fundulus heteroclitus
Contribuinte(s) |
Fabbri, Elena Fuentes, Juan Fonseca, Filomena |
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Data(s) |
22/03/2016
31/12/1969
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Resumo |
Microalgae have been studied because of their great potential as a source of new compounds with important value for biotechnology and to understand their strategies of survival in extreme environments. The microalgae Coccomyxa sp., studied in this thesis, is a poly-extremophile witch was isolated from the acid mine drainage of S. Domingos mine. This environment is characterized by low pH (<3) and high concentration of metals, such as copper and iron. The main purpose of the present work was to evaluate the potential bioactivity in an ex-vivo animal model (Fundulus heteroclitus), and expression on selected genes, of cellular extracts obtained from cultures of Coccomyxa sp. at pH 7 without or with exposure to copper (0.6mM Cu²+). The extracts of Coccomyxa sp. cultured at pH 7 exposed to copper show a great potential to be used as epithelial NKCC inhibitors, revealing their potential use as diuretics, but did not show significant effects on gene expression. Coccomyxa sp. could be a good source of cellular extracts with a great potential to be used in pharmaceutical and biotechnology industries. |
Formato |
application/pdf |
Identificador |
http://amslaurea.unibo.it/9793/1/pompili_mirko_tesi.pdf%27.pdf Pompili, Mirko (2016) Bioactivity of extracts from extremophile microalgae Coccomyxa sp. on chloride cells in operculum tissue of Fundulus heteroclitus. [Laurea magistrale], Università di Bologna, Corso di Studio in Biologia marina [LM-DM270] - Ravenna <http://amslaurea.unibo.it/view/cds/CDS8024/> |
Relação |
http://amslaurea.unibo.it/9793/ |
Direitos |
Free to read |
Palavras-Chave | #Coccomyxa, Polyextremophile, Microalgae, NKCC, Ussing chamber, qPCR, Short circuit current #Biologia marina [LM-DM270] - Ravenna #cds :: 8024 :: Biologia marina [LM-DM270] - Ravenna #sessione :: terza |
Tipo |
PeerReviewed info:eu-repo/semantics/masterThesis |
Idioma(s) |
en |
Publicador |
Alma Mater Studiorum - Università di Bologna |