Identificazione e dosaggio di marcatori molecolari dell'endometriosi nel sangue periferico
Contribuinte(s) |
Caramelli, Elisabetta |
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Data(s) |
14/04/2011
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Resumo |
Purpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis. Methods: a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively. Results: No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate. Conclusions: A combination of serum and molecular markers could allow a better diagnosis of endometriosis. |
Formato |
application/pdf |
Identificador |
http://amsdottorato.unibo.it/3889/1/ELMAKKY__AMIRA_tesi.pdf urn:nbn:it:unibo-2751 Elmakky, Amira (2011) Identificazione e dosaggio di marcatori molecolari dell'endometriosi nel sangue periferico, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze dello sviluppo e del movimento umano: progetto n. 2 "Sviluppo e riproduzione umana" <http://amsdottorato.unibo.it/view/dottorati/DOT422/>, 23 Ciclo. |
Idioma(s) |
it |
Publicador |
Alma Mater Studiorum - Università di Bologna |
Relação |
http://amsdottorato.unibo.it/3889/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Palavras-Chave | #BIO/13 Biologia applicata |
Tipo |
Doctoral Thesis PeerReviewed |