Dendritic cells and T lymphocytes interactions in a novel 3D system
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
09/04/2014
09/04/2014
2013
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| Resumo |
We describe the interactions between monocyte-derived DCs, in different stages of maturation, with allogeneic T lymphocytes in a 3D system. Maturation of DCs increased their interaction time with T lymphocytes from 43 to 138 minutes. The average motility of T lymphocytes interacting or not with DCs was also affected, varying from 0.21μm-0.37μm/minute to 0.36μm- 0.52μm/minute. These data indicate that this 3D BiotekTM scaffold enables interactions between lymphocytes and DCs at different stages of maturation and may be useful for the characterization of these interactions, the cellular subtypes and patterns of response induced. FAPESP, 2010/18139-7 FAPESP, 2009/54599-5 CNPq |
| Identificador |
Procedia Engineering, Maryland Heights, v.59, p.166-173, 2013 http://www.producao.usp.br/handle/BDPI/44437 10.1016/j.proeng.2013.05.107 |
| Idioma(s) |
eng |
| Publicador |
Elsevier Maryland Heights |
| Relação |
Procedia Engineering |
| Direitos |
restrictedAccess Elsevier Ltd. |
| Palavras-Chave | #Dendritic cell #Cellular interactions #Cell motility #T lymphocytes #3D culture systems #CÉLULAS DENDRÍTICAS #INTERAÇÕES CELULARES #LINFÓCITOS T |
| Tipo |
article original article publishedVersion |
