Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
04/11/2013
04/11/2013
2012
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Resumo |
Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies. |
Identificador |
Quím. Nova,v.35,n.3,p.460-465,2012 0100-4042 http://www.producao.usp.br/handle/BDPI/38588 10.1590/S0100-40422012000300004 http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-40422012000300004&lng=en&nrm=iso&tlng=en |
Idioma(s) |
eng |
Publicador |
Sociedade Brasileira de Química |
Relação |
Química Nova |
Direitos |
openAccess |
Palavras-Chave | #piplartine #LC-MS #rat plasma analysis |
Tipo |
article original article |