The immunomodulatory role of carbon monoxide during transplantation
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
14/10/2013
14/10/2013
2013
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Resumo |
The number of organ and tissue transplants has increased worldwide in recent decades. However, graft rejection, infections due to the use of immunosuppressive drugs and a shortage of graft donors remain major concerns. Carbon monoxide (CO) had long been regarded solely as a poisonous gas. Ultimately, physiological studies unveiled the endogenous production of CO, particularly by the heme oxygenase (HO)-1 enzyme, recognizing CO as a beneficial gas when used at therapeutic doses. The protective properties of CO led researchers to develop uses for it, resulting in devices and molecules that can deliver CO in vitro and in vivo. The resulting interest in clinical investigations was immediate. Studies regarding the CO/HO-1 modulation of immune responses and their effects on various immune disorders gave rise to transplantation research, where CO was shown to be essential in the protection against organ rejection in animal models. This review provides a perspective of how CO modulates the immune system to improve transplantation and suggests its use as a therapy in the field. This work was supported by CNPq (CNPq/Inserm, INCT Complex Fluids, MCT/CNPq/FINEP 559887/2010-8 PNPD 159018/2011-0) and FAPESP (12/02270-2). |
Identificador |
Medical Gas Research, London, v.3, p.1-15, 2013 2045-9912 http://www.producao.usp.br/handle/BDPI/34994 10.1186/2045-9912-3-1 |
Idioma(s) |
eng |
Publicador |
London |
Relação |
Medical Gas Research |
Direitos |
openAccess Amano and Camara; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Palavras-Chave | #CO #HO-1 #Immune response #Transplant |
Tipo |
article original article publishedVersion |