Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
14/10/2013
14/10/2013
2013
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| Resumo |
This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process. |
| Identificador |
Journal of Otolaryngology - Head and Neck Surgery, London, v.42, p.1-5, 2013 1916-0216 http://www.producao.usp.br/handle/BDPI/34989 http://dx.doi.org/10.1186/1916-0216-42-27 10.1186/1916-0216-42-27 |
| Idioma(s) |
eng |
| Publicador |
BioMed Central London |
| Relação |
Journal of Otolaryngology - Head and Neck Surgery |
| Direitos |
openAccess Pezato et al.; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Palavras-Chave | #Airway remodeling #Superantigens #Nasal polyps |
| Tipo |
article original article publishedVersion |
