Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
22/10/2013
22/10/2013
2012
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Resumo |
Clin Microbiol Infect 2012; 18: E380E388 Abstract In this randomized clinical trial, the clinical and mycological efficacy of Photodynamic Therapy (PDT) was compared with that of topical antifungal therapy for the treatment of denture stomatitis (DS) and the prevalence of Candida species was identified. Patients were randomly assigned to one of two groups (n = 20 each); in the nystatin (NYT) group patients received topical treatment with nystatin (100 000 IU) four times daily for 15 days and in the PDT group the denture and palate of patients were sprayed with 500 mg/L of Photogem (R), and after 30 min of incubation, were illuminated by light emitting-diode light at 455 nm (37.5 and 122 J/cm2, respectively) three times a week for 15 days. Mycological cultures taken from dentures and palates and standard photographs of the palates were taken at baseline (day 0), at the end of the treatment (day 15) and at the follow-up time intervals (days 30, 60 and 90). Colonies were quantified (CFU/mL) and identified by biochemical tests. Data were analysed by Fishers exact test, analysis of variance and Tukey tests and ? test (a = 0.05). Both treatments significantly reduced the CFU/mL at the end of the treatments and on day 30 of the follow-up period (p <0.05). The NYT and PDT groups showed clinical success rates of 53% and 45%, respectively. Candida albicans was the most prevalent species identified. PDT was as effective as topical nystatin in the treatment of DS. FAPESPSao Paulo Research Council FAPESP-Sao Paulo Research Council [2005/02193-4, 2005/03226-3, 2010/01212-3] CePOFCEPID Program (Center for Research in Optics and PhotonicsCenter for Research, Innovation and Diffusion) CePOF-CEPID Program (Center for Research in Optics and Photonics-Center for Research, Innovation and Diffusion) |
Identificador |
CLINICAL MICROBIOLOGY AND INFECTION, HOBOKEN, v. 18, n. 10, supl. 1, Part 1, pp. E380-E388, OCT, 2012 1198-743X http://www.producao.usp.br/handle/BDPI/35456 10.1111/j.1469-0691.2012.03933.x |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL HOBOKEN |
Relação |
CLINICAL MICROBIOLOGY AND INFECTION |
Direitos |
closedAccess Copyright WILEY-BLACKWELL |
Palavras-Chave | #CANDIDA #LIGHT-EMITTING DIODE #NYSTATIN #ORAL CANDIDIASIS #PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY #PORPHYRIN #CANDIDA-ALBICANS #MURINE MODEL #RESISTANCE #COLONIZATION #INACTIVATION #GLABRATA #SPP. #INFECTIOUS DISEASES #MICROBIOLOGY |
Tipo |
article original article publishedVersion |