Quercetin as a shuttle for labile iron
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
21/10/2013
21/10/2013
2012
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| Resumo |
The antioxidant activity of flavonoids may involve their ability to complex body iron in non-redox-active forms. In this study, it was found that the catechol flavonoids rutin and quercetin are able to suppress redox-active labile plasma iron (LPI) in both buffered solution and in iron-overloaded sera. Both flavonoids are effective in loading the metal into the iron-transport protein transferrin. Iron derivatives of quercetin and rutin are able to permeate cell membranes, however, only free quercetin is able to gain access to the cytosol and decrease intracellular labile iron pools. These results suggest that the antioxidant activity of quercetin may be dependent on its ability to shuttle labile iron from cell compartments followed by its transfer to transferrin. (C) 2011 Elsevier Inc. All rights reserved. Brazilian government agency CNPq CNPq (Brazilian government agency) FAPESP (Brazilian government agency) Brazilian government agency FAPESP |
| Identificador |
JOURNAL OF INORGANIC BIOCHEMISTRY, NEW YORK, v. 107, n. 1, p. 34-39, FEB, 2012 0162-0134 http://www.producao.usp.br/handle/BDPI/35234 10.1016/j.jinorgbio.2011.11.014 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE INC NEW YORK |
| Relação |
Journal of Inorganic Biochemistry |
| Direitos |
closedAccess Copyright ELSEVIER SCIENCE INC |
| Palavras-Chave | #IRON #QUERCETIN #RUTIN #ANTIOXIDANT #FLAVONOID #OVERLOAD #TRANSFERRIN-BOUND IRON #RAT HEPATOCYTE CULTURES #HUMAN-ERYTHROCYTES #PLASMA IRON #CELL IRON #FLAVONOIDS #OVERLOAD #ANTIOXIDANT #RUTIN #MECHANISMS #BIOCHEMISTRY & MOLECULAR BIOLOGY #CHEMISTRY, INORGANIC & NUCLEAR |
| Tipo |
article original article publishedVersion |
