Risk factors for hepatitis C virus infection in Inland Brazil: An analysis of pooled epidemiological sectional studies
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
07/11/2013
07/11/2013
2012
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Resumo |
In order to assess the contribution of different parenteral routes as risk exposure to the hepatitis C virus (HCV), samples from nine surveys or cross-sectional studies conducted in two Brazilian inland regions were pooled, including a total of 3,910 subjects. Heterogeneity among the study results for different risk factors was tested and the results were shown to be homogeneous. Anti-HCV antibodies were observed in 241 individuals, of which 146 (3.7%, 95% CI?=?3.24.4) had HCV exposure confirmed by immunoblot analysis or PCR test. After adjustment for relevant variables, a correlation between confirmed HCV exposure and injection drug use, tattooing, and advance age was observed. In a second logistic model that included exposures not searched in all nine studies, a smaller sample was analyzed, revealing an independent HCV association with past history of surgery and males who have sex with other males, in addition to repeated injection drug use. Overall, these analyses corroborate the finding that injection drug use is the main risk factor for HCV exposure and spread, in addition to other parenteral routes. J. Med. Virol. 84:756762, 2012. (C) 2012 Wiley Periodicals, Inc. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) of Brazilian Education Ministry Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) |
Identificador |
JOURNAL OF MEDICAL VIROLOGY, MALDEN, v. 84, n. 5, pp. 756-762, MAY, 2012 0146-6615 http://www.producao.usp.br/handle/BDPI/42945 10.1002/jmv.23256 |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL MALDEN |
Relação |
JOURNAL OF MEDICAL VIROLOGY |
Direitos |
closedAccess Copyright WILEY-BLACKWELL |
Palavras-Chave | #BLOOD BORNE INFECTIONS #PARENTERAL TRANSMISSION #INJECTION DRUG USE #BLOOD TRANSFUSION #TATTOO #INJECTION-DRUG USERS #UNITED-STATES #MATO-GROSSO #PREVALENCE #TRANSMISSION #AMAZON #ASSOCIATION #PRISON #VIROLOGY |
Tipo |
article original article publishedVersion |