Heparin Increases HLA-G Levels in Primary Antiphospholipid Syndrome
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
---|---|
Data(s) |
06/11/2013
06/11/2013
2012
|
Resumo |
Objectives. The aim of this study was to investigate the HLA-G serum levels in Primary Antiphospholipid Syndrome (PAPS) patients, its impact on clinical and laboratory findings, and heparin treatment. Methods. Forty-four PAPS patients were age and gender matched with 43 controls. HLA-G serum levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results. An increase in soluble HLA-G levels was found in patients compared to controls (3.35 (0 22.9) versus 1.1 (0 14), P = 0.017). There were no significant differences in HLA-G levels between patients with and without obstetric events, arterial thrombosis, venous thrombosis, or stroke. Sixty-six percent of patients were being treated with heparin. Interestingly, patients treated with heparin had higher HLA-G levels than ones who were not treated with this medication (5 (0-22.9) versus 1.8 (0-16) ng/mL, P = 0.038). Furthermore, patients on heparin who experienced obstetric events had a trend to increased HLA-G levels compared to patients who were not on heparin and did not have obstetric events (5.8 (0-22.9) versus 2 (0-15.2) ng/mL, P = 0.05). Conclusion. This is the first study to demonstrate that serum HLA-G levels are increased in APS patients. We also demonstrated that heparin increases HLA-G levels and may increase tolerance towards autoantigens. |
Identificador |
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, NEW YORK, v. 2012, pp. 29-35, MAY, 2012 1740-2522 http://www.producao.usp.br/handle/BDPI/41953 10.1155/2012/232390 |
Idioma(s) |
eng |
Publicador |
HINDAWI PUBLISHING CORPORATION NEW YORK |
Relação |
CLINICAL & DEVELOPMENTAL IMMUNOLOGY |
Direitos |
openAccess Copyright HINDAWI PUBLISHING CORPORATION |
Palavras-Chave | #SYSTEMIC-LUPUS-ERYTHEMATOSUS #INFLAMMATORY MYOPATHIES #T-CELLS #EXPRESSION #ANTIGEN #ASSOCIATION #POLYMORPHISM #MOLECULE #PLASMA #IMMUNOLOGY |
Tipo |
article original article publishedVersion |