Assessment of the sublethal toxicity of organochlorine pesticide endosulfan in juvenile common carp (Cyprinus carpio)
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
05/11/2013
05/11/2013
2012
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Resumo |
This study is aimed at evaluating the sublethal effects of endosulfan (EDS) in juvenile common carp (Cyprinus carpio). For this purpose, fish were exposed for 15 days to the technical EDS (95% pure) diluted in dimethyl sulfoxide (DMSO) 0.1% of the total volume in water solution in a semi-static system at sublethal concentration (1 mu g/L). Subsequently, the liver somatic index (LSI) and factor condition (K) were determined. The total cytocrome P450 (CYP), CYP1A isoform, and the ethoxyresorufin-O-deethylase (EROD) activity were determined from the hepatic microsomal fraction as well as the activity of the oxidative stress enzyme system such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GP(X)), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PDH). Among the parameters assessed, EDS at the sublethal concentration in subchronic exposure caused significant changes in liver somatic indices as well as induction of the phase I biotransformation system and oxidative stress in juvenile common carp (Cyprinus carpio). Thus, it is seen that the use of biochemical biomarkers of environmental contamination in this study proved to be an extremely important tool for detecting the adverse effects of xenobiotics in the aquatic environment, even at low concentration. Sao Paulo Research Foundation, Brazil. (FAPESP) [1999/12198-0] Sao Paulo Research Foundation (FAPESP, Brazil) |
Identificador |
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, PHILADELPHIA, v. 47, n. 11, supl. 1, Part 2, pp. 1652-1658, FEB, 2012 1093-4529 http://www.producao.usp.br/handle/BDPI/41160 10.1080/10934529.2012.687236 |
Idioma(s) |
eng |
Publicador |
TAYLOR & FRANCIS INC PHILADELPHIA |
Relação |
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING |
Direitos |
restrictedAccess Copyright TAYLOR & FRANCIS INC |
Palavras-Chave | #ENDOSULFAN #CYPRINUS CARPIO #EROD #CYP1A #CYTOCHROME P450 #OXIDATIVE STRESS #RESIDUES #LIVER #FISH #CYTOCHROME-P-450 #RESPONSES #BINDING #SYSTEM #MODEL #MILK #ENGINEERING, ENVIRONMENTAL #ENVIRONMENTAL SCIENCES |
Tipo |
article original article publishedVersion |