Diversity of the KIR gene cluster in an urban Brazilian population
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
The activity of natural killer cells depends on the balance between activating and inhibitory signals coming from their receptors. Among these are the killer cell immunoglobulin-like receptors (KIR) that recognize specific HLA class I allotypes. Here we characterized KIR genetic diversity and their HLA ligands in the population of Curitiba, Parana State (n = 164), and compared it with other worldwide populations. The distribution of 2DL4 alleles was also analyzed. The Curitiba population did not differ significantly from European and Euro-descendant populations, but as an admixed population showed higher genetic diversity. We found 27 KIR profiles, many of them uncommon in European populations, in agreement with the elevated historically recent gene flow in the study population. The frequencies of KIR genes and their respective HLA ligands were distributed independently and none of the analyzed individuals lacked functional KIR-HLA ligand combinations. KIR gene frequencies of 33 worldwide populations were consistent with geographic and ethnic distribution, in agreement with demography being the major factor shaping the observed gene content diversity of the KIR locus. Laboratory of Human Molecular Genetics at the Department of Genetics of the Federal University of Parana Laboratory of Human Molecular Genetics at the Department of Genetics of the Federal University of Parana Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) PRONEX PRONEX Institutos do Milenio Institutos do Milenio Fundacao Araucaria Fundacao Araucaria Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) National Cancer Institute, National Institutes of Health National Cancer Institute, National Institutes of Health [HHSN261200800001E] NIH, National Cancer Institute, Center for Cancer Research NIH, National Cancer Institute, Center for Cancer Research |
| Identificador |
IMMUNOGENETICS, NEW YORK, v. 64, n. 2, supl. 4, Part 1-2, pp. 143-152, FEB, 2012 0093-7711 http://www.producao.usp.br/handle/BDPI/41761 10.1007/s00251-011-0565-1 |
| Idioma(s) |
eng |
| Publicador |
SPRINGER NEW YORK |
| Relação |
IMMUNOGENETICS |
| Direitos |
closedAccess Copyright SPRINGER |
| Palavras-Chave | #KIR GENES #KIR DIVERSITY #BRAZILIAN POPULATION #HLA LIGANDS #2DL4 ALLELE FREQUENCIES #IMMUNOGLOBULIN-LIKE RECEPTOR #NATURAL-KILLER-CELLS #CHROMOSOME 19Q13.4 #HAPLOTYPE ANALYSIS #NK CELLS #HLA-C #KIR2DL4 #ALLELES #POLYMORPHISMS #DISEASE #GENETICS & HEREDITY #IMMUNOLOGY |
| Tipo |
article original article publishedVersion |
