SENSITIVE METHOD FOR DETERMINATION OF PIPLARTINE, AN ALKALOID AMIDE FROM Piper SPECIES, IN RAT PLASMA SAMPLES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies. CNPq CNPq CAPES CAPES Instituto Claude Bernard Instituto Claude Bernard FUNCAP FUNCAP Banco do Nordeste Banco do Nordeste FINEP FINEP |
| Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 3, supl., Part 1-2, pp. 460-465, SEP, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/41047 10.1590/S0100-40422012000300004 |
| Idioma(s) |
eng |
| Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
| Relação |
QUIMICA NOVA |
| Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
| Palavras-Chave | #PIPLARTINE #LC-MS/MS #RAT PLASMA ANALYSIS #CYTOTOXIC PYRIDONE ALKALOIDS #NATURAL-PRODUCTS #IN-VITRO #TUBERCULATUM #LONGUM #CONSTITUENTS #INHIBITION #ABORESCENS #MEDICINE #HERBS #CHEMISTRY, MULTIDISCIPLINARY |
| Tipo |
article original article publishedVersion |
