Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
We investigated whether three relevant polymorphisms (C-1562T, microsatellite - 90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients. (C) 2012 Elsevier B.V. All rights reserved. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) |
| Identificador |
JOURNAL OF NEUROIMMUNOLOGY, AMSTERDAM, v. 252, n. 41306, supl. 1, Part 3, pp. 89-94, 42309, 2012 0165-5728 http://www.producao.usp.br/handle/BDPI/40987 10.1016/j.jneuroim.2012.07.016 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV AMSTERDAM |
| Relação |
JOURNAL OF NEUROIMMUNOLOGY |
| Direitos |
closedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #HAPLOTYPE #MATRIX METALLOPROTEINASE-9 #MIGRAINE #POLYMORPHISM #TIMP-1 #MATRIX-METALLOPROTEINASE (MMP)-2 #BLOOD-BRAIN-BARRIER #CARDIOVASCULAR-DISEASE #HEMORRHAGIC TRANSFORMATION #GENETIC-POLYMORPHISM #HEALTHY-SUBJECTS #OBESE CHILDREN #STROKE #NEUROBIOLOGY #HYPERTENSION #IMMUNOLOGY #NEUROSCIENCES |
| Tipo |
article original article publishedVersion |
