Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis


Autoria(s): Buzalaf, M. A. R.; Massaro, C. S.; Rodrigues, M. H. C.; Fukushima, R.; Pessan, Juliano Pelim; Whitford, G. M.; Sampaio, F. C.
Contribuinte(s)

Universidade de São Paulo

Data(s)

20/09/2013

20/09/2013

01/12/2012

Resumo

The aim of this study was to validate the use of fingernail fluoride concentrations at ages 2-7 years as predictors of the risk for developing dental fluorosis in the permanent dentition. Fifty-six children of both genders (10-15 years of age) had their incisors and premolars examined for dental fluorosis using the Thylstrup-Fejerskov index. Fingernail fluoride concentrations were obtained from previous studies when children were 2-7 years of age. Data were analyzed by unpaired t test, ANOVA, and Fisher's exact test when the fingernail fluoride concentrations were dichotomized (<= 2 or > 2 mu g/g). Children with dental fluorosis had significantly higher fingernail fluoride concentrations than those without the condition, and the concentrations tended to increase with the severity of fluorosis (r(2) = 0.47, p < 0.0001). Using a fingernail fluoride concentration of 2 mu g/g at ages 2-7 years as a threshold, this biomarker had high sensitivity (0.84) and moderate specificity (0.53) as a predictor for dental fluorosis. The high positive predictive value indicates that fingernail fluoride concentrations should be useful in public health research, since it has the potential to identify around 80% of children at risk of developing dental fluorosis. Copyright (C) 2012 S. Karger AG, Basel

CAPES

CNPq [576703/2008-7]

FAPESP [01/00237-3, 02/07875-8]

Identificador

Caries Research, Basel, v. 46, n. 4, pp. 394-400, Dec 5, 2012

0008-6568

http://www.producao.usp.br/handle/BDPI/33522

10.1159/000339088

http://dx.doi.org/10.1159/000339088

Idioma(s)

eng

Publicador

Karger

Basel

Relação

Caries Research

Direitos

openAccess

Copyright Karger

Palavras-Chave #Biomarker #Dental Fluorosis #Fingernail #Fluoride #MAXILLARY CENTRAL INCISORS #ENAMEL FLUOROSIS #EXPOSURE #PREVALENCE #BIOMARKERS #DENTIFRICE #CHILDREN #BRAZIL #BAURU #BIOMARCADORES #FLUOROSE DENTÁRIA #FLUORETO #DENTISTRY, ORAL SURGERY & MEDICINE
Tipo

article

original article

publishedVersion