Ankle-Brachial Index: A Simple Way to Predict Mortality among Patients on Hemodialysis - A Prospective Study
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
04/11/2013
04/11/2013
2012
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Resumo |
Background: Ankle-brachial index (ABI) can access peripheral artery disease and predict mortality in prevalent patients on hemodialysis. However, ABI has not yet been tested in incident patients, who present significant mortality. Typically, ABI is measured by Doppler, which is not always available, limiting its use in most patients. We therefore hypothesized that ABI, evaluated by a simplified method, can predict mortality in an incident hemodialysis population. Methodology/Principal Findings: We studied 119 patients with ESRD who had started hemodialysis three times weekly. ABI was calculated by using two oscillometric blood pressure devices simultaneously. Patients were followed until death or the end of the study. ABI was categorized in two groups normal (0.9-1.3) or abnormal (<0.9 and >1.3). There were 33 deaths during a median follow-up of 12 months (from 3 to 24 months). Age (1 year) (hazard of ratio, 1.026; p = 0.014) and ABI abnormal (hazard ratio, 3.664; p = 0.001) were independently related to mortality in a multiple regression analysis. Conclusions: An easy and inexpensive technique to measure ABI was tested and showed to be significant in predicting mortality. Both low and high ABI were associated to mortality in incident patients on hemodialysis. This technique allows nephrologists to identify high-risk patients and gives the opportunity of early intervention that could alter the natural progression of this population. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Brazil |
Identificador |
PLOS ONE, SAN FRANCISCO, v. 7, n. 7, supl. 4, Part 1-2, pp. 69-78, 11140, 2012 1932-6203 http://www.producao.usp.br/handle/BDPI/37818 10.1371/journal.pone.0042290 |
Idioma(s) |
eng |
Publicador |
PUBLIC LIBRARY SCIENCE SAN FRANCISCO |
Relação |
PLOS ONE |
Direitos |
openAccess Copyright PUBLIC LIBRARY SCIENCE |
Palavras-Chave | #CHRONIC KIDNEY-DISEASE #BLOOD-PRESSURE INDEX #PULSE-WAVE VELOCITY #RENAL DATA SYSTEM #UNITED-STATES #CARDIOVASCULAR-DISEASE #DIALYSIS #HEALTH #MULTIDISCIPLINARY SCIENCES |
Tipo |
article original article publishedVersion |