Inhibiting effect of Dorstenia asaroides extracts on cariogenic properties of Streptococcus mutans
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
31/10/2013
31/10/2013
2012
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Resumo |
The aim of this study was to examine the effects of Dorstenia asaroides extracts on cariogenic properties of the most cariogenic bacteria, Streptococcus mutans. Hexane (HFr), ethyl-acetate (EFr) and chloroform (CFr) extracts obtained from D. asaroides rhizomes were submitted to chemical analyses, Minimal Inhibitory Concentrations (MIC), glycolysis assay and S. mutans 12-h-old initial biofilms. Chemical characterization showed that all the extracts present furanocoumarins. The MIC values were 80 (HFr and CFr) and 50 mu g/mL (EFr). Acid production by S. mutans cells was significantly disrupted by HFr (12.5 mg/mL), EFr (at 2.5; 6.25 and 12.5 mg/mL) and CFr (at 2.5, 6.25 and 12.5 mg/mL) (p < 0.01). Topical applications of HFr, EFr and CFr significantly reduced the colony forming units of S. mutans biofilms compared with those treated with control group in order to 20,30 and 25% respectively (p < 0.01). The results of the present study suggest that rhizomes of D. asaroides had inhibitory effects on cariogenic properties of S. mutans. (C) 2012 Elsevier Ltd. All rights reserved. |
Identificador |
ANAEROBE, OXFORD, v. 18, n. 1, supl., Part 3, pp. 31-36, FEB, 2012 1075-9964 http://www.producao.usp.br/handle/BDPI/37020 10.1016/j.anaerobe.2011.12.020 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCI LTD OXFORD |
Relação |
ANAEROBE |
Direitos |
closedAccess Copyright ELSEVIER SCI LTD |
Palavras-Chave | #ANTIMICROBIAL #BIOFILM #STREPTOCOCCUS MUTANS #DORSTENIA ASAROIDES #INFECTIOUS-DISEASES #BIOFILM FORMATION #PLANT-EXTRACTS #DENTAL PLAQUE #IN-VITRO #FURANOCOUMARINS #ACIDOGENICITY #PRODUCTS #BACTERIA #ADHESION #MICROBIOLOGY |
Tipo |
article original article publishedVersion |