The characteristics of VIM-1-producing Klebsiella pneumoniae from South Africa
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
29/10/2013
29/10/2013
2012
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Resumo |
A study was designed to characterize a carbapenem-resistant Klebsiella pneumoniae (KPSA01) isolated from a patient in Gauteng, South Africa without recent travel outside South Africa. Molecular characterization was done using isoelectric focusing, polymerase chain reaction and sequencing for bla(VIM), bla(IMP), bla(NDM), bla(CTX-Ms), bla(OXAs), bla(TEMs), and bla(SHV), plasmid-mediated quinolone resistance determinants, multilocus sequencing typing, plasmid replicon typing, and addiction factors. KPSA01 produced VIM-1 and belonged to the newly described sequence type ST569. The plasmid that harboured bla(VIM) typed within the narrow host range IncF replicon group, contained the aadA1 gene cassette, and tested positive for the vagCD and ccdAB addiction systems. This is the first report of VIM-1-producing K. pneumoniae outside Europe. It is important that surveillance studies be undertaken in Africa to determine if VIM-1-producing K. pneumoniae are present in significant numbers. Calgary Laboratory Services [73-6350] Calgary Laboratory Services Merck Merck Astra Zeneca AstraZeneca |
Identificador |
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, LONDON, v. 44, n. 1, supl. 1, Part 2, pp. 74-78, JAN, 2012 0036-5548 http://www.producao.usp.br/handle/BDPI/36198 10.3109/00365548.2011.614276 |
Idioma(s) |
eng |
Publicador |
INFORMA HEALTHCARE LONDON |
Relação |
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES |
Direitos |
restrictedAccess Copyright INFORMA HEALTHCARE |
Palavras-Chave | #KLEBSIELLA PNEUMONIAE #METALLO-BETA-LACTAMASES #VIM-1 #NOSOCOMIAL INFECTION #SOUTH AFRICA #METALLO-BETA-LACTAMASE #ESCHERICHIA-COLI #MODIFYING ENZYME #UNITED-STATES #1ST OUTBREAK #ENTEROBACTERIACEAE #EMERGENCE #EPIDEMIOLOGY #INFECTIONS #PREVALENCE #INFECTIOUS DISEASES |
Tipo |
article original article publishedVersion |