Antinociception induced by acute oral administration of sweet substance in young and adult rodents: The role of endogenous opioid peptides chemical mediators and mu(1)-opioid receptors
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
23/10/2013
23/10/2013
2012
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Resumo |
The present work aimed to investigate the effects of acute sucrose treatment on the perception of painful stimuli. Specifically, we sought to determine the involvement of the endogenous opioid peptide-mediated system as well as the role of the mu(1)-opioid receptor in antinociception organisation induced by acute sucrose intake. Nociception was assessed with the tail-flick test in rats (75, 150 and 250 g) of different ages acutely pre-treated with 500 mu L. of a sucrose solution (25, 50, 150 and 250 g/L) or tap water. Young and Adult rats (250 g) showed antinociception after treatment with 50 g/L (during 5 min) and 150 g/L and 250 g/L (during 20 min) sucrose solutions. Surprisingly, this antinociception was more consistent in mature adult rodents than in pups. To evaluate the role of opioid systems, mature adult rodents were pre-treated with different doses (0.25, 1 or 4mg/kg) of the non-selective opioid receptor antagonist naloxone, the selective pi-opioid receptor antagonist naloxonazine or vehicle followed by 250 g/L sucrose solution treatment. Sucrose-induced antinociception was reduced by pre-treatment with both naloxone and naloxonazine. The present findings suggest that sweet substance-induced hypo-analgesia is augmented by increasing sucrose concentrations in young and adult rodents. Acute oral sucrose treatment inhibits pain in laboratory animal by mediating endogenous opioid peptide and mu(1)-opioid receptor actions. (C) 2011 Elsevier Inc. All rights reserved. FAPESP FAPESP [proc. 03/03118-0, proc. 01/03752-6, proc. 03/05256-1, proc. 2009/17258-5, TT-2, proc. 02/01497-1] FAEPA FAEPA [proc. 1291/97, 355/2000, 68/2001, 15/2003, 6/2004] CNPq [proc. 301905/2010-0, proc. 501858/2005-9, proc. 372654/2006-1, proc. 372810/2008-0, proc. 372877/2010-9] CNPq CAPES CAPES |
Identificador |
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, OXFORD, v. 101, n. 2, supl., Part 3, pp. 265-270, APR, 2012 0091-3057 http://www.producao.usp.br/handle/BDPI/35731 10.1016/j.pbb.2011.12.005 |
Idioma(s) |
eng |
Publicador |
PERGAMON-ELSEVIER SCIENCE LTD OXFORD |
Relação |
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR |
Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
Palavras-Chave | #SWEET SUBSTANCE-INDUCED ANTINOCICEPTION #TAIL-FLICK LATENCIES #ENDOGENOUS OPIOID PEPTIDES #MU(1)-OPIOID RECEPTORS #RATTUS-NORVEGICUS RODENTIA #DORSAL RAPHE NUCLEUS #INDUCED ANALGESIA #MORPHINE ANALGESIA #FEEDING-BEHAVIOR #PAIN MODELS #RATS #SUCROSE #INVOLVEMENT #TOLERANCE #BEHAVIORAL SCIENCES #NEUROSCIENCES #PHARMACOLOGY & PHARMACY |
Tipo |
article original article publishedVersion |