Lupus erythematosus panniculitis in children and adolescents


Autoria(s): Guissa, Vanessa R.; Trudes, Guilherme; Jesus, Adriana A.; Aikawa, Nadia E.; Romiti, Ricardo; Silva, Clovis A.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

23/10/2013

23/10/2013

2012

Resumo

Introduction: Lupus erythematosus panniculitis (LEP) or lupus erythematosus profundus is a rare form of chronic cutaneous manifestation affecting both adults and pediatric patients. The prevalence of this manifestation was seldom reported in juvenile systemic lupus erythematosus (JSLE). Case reports: From January 1983 to December 2010, 5,506 patients were followed at the Pediatric Rheumatology Unit of our University Hospital and 278 (5%) of them met the American College of Rheumatology classification criteria for JSLE. Two (0.7%) of them had LEP at JSLE onset. These two cases had tender deep inflammatory subcutaneous nodules or plaques at the time of diagnosis, and the histopathologic pattern evidenced lobular or mixed panniculitis with lymphocytic inflammatory cells of the fat lobule. Treatments for LEP included mainly antimalarials, systemic corticosteroids and sunscreen protection. One male patient required thalidomide and immunosuppressive drugs, including mycophenolate mofetil, cyclosporin and intravenous cyclophosphamide. However, skin lesions improved only after rituximab treatment. Discussion: LEP was rarely observed in our cohort of JSLE patients as the first lupus manifestation. Anti-CD20 monoclonal antibody therapy may be an option for refractory LEP treatment in children.

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [08/58238]

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

CNPq

CNPQ [300248/2008-3]

Federico Foundation

Federico Foundation

Identificador

ACTA REUMATOLOGICA PORTUGUESA, ALGES, v. 37, n. 1, supl. 1, Part 1-2, pp. 82-85, JAN-MAR, 2012

0303-464X

http://www.producao.usp.br/handle/BDPI/35603

Idioma(s)

eng

Publicador

MEDFARMA-EDICOES MEDICAS, LDA

ALGES

Relação

ACTA REUMATOLOGICA PORTUGUESA

Direitos

openAccess

Copyright MEDFARMA-EDICOES MEDICAS, LDA

Palavras-Chave #PANNICULITIS #AUTOIMMUNE #CHILDREN #JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS #RITUXIMAB #CUTANEOUS MANIFESTATIONS #RHEUMATOLOGY
Tipo

article

original article

publishedVersion