A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, Sao Paulo, Brazil
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/08/2013
20/08/2013
01/09/2012
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Resumo |
Monitoring the extent of and trends in multidrug-resistant tuberculosis (MDR-TB) is a priority of the Brazilian National Tuberculosis Control Programme. The current study aimed to estimate the incidence of MDR-TB, describe the profile of TB drug resistance in risk groups and examine whether screening for MDR-TB adhered to the recommended guidelines. A descriptive study that examined diagnosed cases of pulmonary TB was conducted in the city of Santos, Brazil, between 2000-2004. Of the 2,176 pulmonary TB cases studied, 671 (30.8%) met the criteria for drug sensitivity testing and, of these cases, 31.7% (213/671) were tested. Among the tested cases, 9.4% were resistant to one anti-TB drug and 15% were MDR. MDR was observed in 11.6% of 86 new TB cases and 17.3% of 127 previously treated cases. The average annual incidence of MDR-TB was 1.9 per 100,000 inhabitants-years. The extent of known MDR-TB in the city of Santos is high, though likely to be underestimated. Our study therefore indicates an inadequate adherence to the guidelines for MDR-TB screening and suggests the necessity of alternative strategies of MDR-TB surveillance. CNPq CNPq [307728/2009-9] ICOHRTAAIDS/TB ICOHRTA-AIDS/TB |
Identificador |
MEMORIAS DO INSTITUTO OSWALDO CRUZ, RIO DE JANEIRO, RJ, v. 107, n. 6, pp. 760-766, SEP, 2012 0074-0276 http://www.producao.usp.br/handle/BDPI/32631 10.1590/S0074-02762012000600009 |
Idioma(s) |
eng |
Publicador |
FUNDACO OSWALDO CRUZ RIO DE JANEIRO, RJ |
Relação |
MEMORIAS DO INSTITUTO OSWALDO CRUZ |
Direitos |
openAccess Copyright FUNDACO OSWALDO CRUZ |
Palavras-Chave | #PULMONARY TUBERCULOSIS #DRUG RESISTANCE #MULTIDRUG RESISTANCE #SURVEILLANCE #DRUG-RESISTANCE #MYCOBACTERIUM-TUBERCULOSIS #TRANSMISSION #PARASITOLOGY #TROPICAL MEDICINE |
Tipo |
article original article publishedVersion |