A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, Sao Paulo, Brazil


Autoria(s): Vieira Coelho, Andrea Gobetti; Zamarioli, Liliana Aparecida; Telles, Maria Alice; Ferrazoli, Lucilaine; Waldman, Eliseu Alves
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/08/2013

20/08/2013

01/09/2012

Resumo

Monitoring the extent of and trends in multidrug-resistant tuberculosis (MDR-TB) is a priority of the Brazilian National Tuberculosis Control Programme. The current study aimed to estimate the incidence of MDR-TB, describe the profile of TB drug resistance in risk groups and examine whether screening for MDR-TB adhered to the recommended guidelines. A descriptive study that examined diagnosed cases of pulmonary TB was conducted in the city of Santos, Brazil, between 2000-2004. Of the 2,176 pulmonary TB cases studied, 671 (30.8%) met the criteria for drug sensitivity testing and, of these cases, 31.7% (213/671) were tested. Among the tested cases, 9.4% were resistant to one anti-TB drug and 15% were MDR. MDR was observed in 11.6% of 86 new TB cases and 17.3% of 127 previously treated cases. The average annual incidence of MDR-TB was 1.9 per 100,000 inhabitants-years. The extent of known MDR-TB in the city of Santos is high, though likely to be underestimated. Our study therefore indicates an inadequate adherence to the guidelines for MDR-TB screening and suggests the necessity of alternative strategies of MDR-TB surveillance.

CNPq

CNPq [307728/2009-9]

ICOHRTAAIDS/TB

ICOHRTA-AIDS/TB

Identificador

MEMORIAS DO INSTITUTO OSWALDO CRUZ, RIO DE JANEIRO, RJ, v. 107, n. 6, pp. 760-766, SEP, 2012

0074-0276

http://www.producao.usp.br/handle/BDPI/32631

10.1590/S0074-02762012000600009 

http://dx.doi.org/10.1590/S0074-02762012000600009 

Idioma(s)

eng

Publicador

FUNDACO OSWALDO CRUZ

RIO DE JANEIRO, RJ

Relação

MEMORIAS DO INSTITUTO OSWALDO CRUZ

Direitos

openAccess

Copyright FUNDACO OSWALDO CRUZ

Palavras-Chave #PULMONARY TUBERCULOSIS #DRUG RESISTANCE #MULTIDRUG RESISTANCE #SURVEILLANCE #DRUG-RESISTANCE #MYCOBACTERIUM-TUBERCULOSIS #TRANSMISSION #PARASITOLOGY #TROPICAL MEDICINE
Tipo

article

original article

publishedVersion