The role of qualea multiflora on mammary tumour cells and immune system
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
28/01/2016
28/01/2016
2013
|
Resumo |
Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-a) and the transcription factor NF-κB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-a; about 32% of NF-κB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted. |
Formato |
8-13 |
Identificador |
Journal of Applied Pharmaceutical Science, v. 3, n. 9, p. 8-13, 2013. 2231-3354 http://hdl.handle.net/11449/133707 1730146818754269 2475607853580549 7927877224326837 |
Idioma(s) |
eng |
Relação |
Journal of Applied Pharmaceutical Science |
Direitos |
closedAccess |
Tipo |
info:eu-repo/semantics/article |