Effect of Raloxifene on Periapical Lesions in Ovariectomized Rats
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
21/10/2015
21/10/2015
01/05/2015
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Resumo |
Introduction: The aim of this study was to evaluate the effect of raloxifene (RLX) during progression of periapical lesions in ovariectomized (OVX) rats. Methods: Female Wistar rats were OVX or subjected to sham surgery and received vehicle or MX by gavage for 90 days. The treatment groups were as follows: sham surgery and treated with vehicle (SHAM-veh), OVX and treated with vehicle (OVX-veh), and OVX and treated with RLX (OVX-RLX). During treatment, the pulp of lower first molar was exposed to the oral. environment for induction of periapical lesion that was analyzed 7 or 30 days aftdr procedure. Blood samples were taken from jugular vein for measurement of estradiol, and the mandibles were removed and prepared for radiographic, histopathologic, histometric, and immunohistochemical analysis. Results: Estradiol plasma concentration showed hypoestrogenism in OVX rats. The histopathologic analysis of the OVX/RLX group was similar to that of the SHAM-veh group, whereas OVX-veh group showed larger penapical lesions with more intense inflammatory response and more cells positive for tartrate-resistant acid phosphatase. Radiographically, the groups were similar, but lesions on day 7 were smaller than lesions on day 30. Conclusions: The results suggest that hypoestrogenism potentiates the progression of periapical lesions, and such condition was reversed by treatment with RLX. |
Formato |
671-675 |
Identificador |
http://www.sciencedirect.com/science/article/pii/S0099239914011431 Journal Of Endodontics. New York: Elsevier Science Inc, v. 41, n. 5, p. 671-675, 2015. 0099-2399 http://hdl.handle.net/11449/128513 http://dx.doi.org/10.1016/j.joen.2014.11.027 WOS:000354597200016 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Journal Of Endodontics |
Direitos |
closedAccess |
Palavras-Chave | #Bone metabolism #estrogen #ovariectomized #periapical lesion #raloxifene |
Tipo |
info:eu-repo/semantics/article |