The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis, and parasitic diseases


Autoria(s): Dias, Fabricio C.; Castelli, Erick C.; Collares, Cristhianna V. A.; Moreau, Philippe; Donadil, Eduardo A.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

21/10/2015

21/10/2015

02/02/2015

Resumo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to be advantageous in autoimmune disorders. The expression of HLA-G on tissue or peripheral blood cells, the levels of soluble HLA-G and polymorphic sites along the gene have been studied in several disorders. In this study, we revised the role of the molecule and polymorphic sites along the HLA-G gene in tumors, viral hepatitis, and parasitic disorders. Overall, several lines of evidence clearly show that the induction of HLA-G expression in tumors has been associated with worse disease outcome and disease spread. In addition, the few studies conducted on hepatitis and parasitic disorders indicate that HLA-G may contribute to disease pathogenesis. Few isolated polymorphic sites, primarily located at the coding or 3'untranslated HLA-G region, have been evaluated in these disorders, and a complete HLA-G typing together with the study of gene regulatory elements may further help on the understanding of the influence of the genetic background on disease susceptibility.

Formato

1-10

Identificador

http://journal.frontiersin.org/Article/10.3389/fimmu.2015.00009/abstract

Frontiers In Immunology. Lausanne: Frontiers Research Foundation, v. 6, p. 1-10, 2015.

1664-3224

http://hdl.handle.net/11449/128368

http://dx.doi.org/10.3389/fimmu.2015.00009

WOS:000354758800001

WOS000354758800001.pdf

Idioma(s)

eng

Publicador

Frontiers Research Foundation

Relação

Frontiers In Immunology

Direitos

openAccess

Palavras-Chave #HLA-G #Tumors #Viral hepatitis #Parasitic disorders #Polymorphism
Tipo

info:eu-repo/semantics/review