Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens


Autoria(s): Resende, Flavia A.; Silva Almeida, Carolina P. da; Vilegas, Wagner; Varanda, Eliana Aparecida
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

03/12/2014

03/12/2014

15/07/2014

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

The antimutagenicity of ten flavonoids, differing in their hydroxylation patterns against direct-acting and indirect-acting mutagens, namely 4-nitro-o-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin B-1 and 2-aminofluorene, were compared with the aim of investigating how the hydroxyl groups in their structures govern the biological activity of flavonoids, by the Ames test, with Salmonella typhimurium strains TA98, TA100 and TA102. The flavonoids tested were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In these tests, all compounds were shown to be antimutagenic in more than one strain and various mechanisms of action were demonstrated. The results suggested that the number and position of hydroxyl groups may increase or decrease the protective effect, depending on the type and concentration of flavonoids and mutagen used. These studies contribute to clarifying the mechanisms by which these flavonoids act in protecting DNA from damage. This is required before they can be widely used. (C) 2014 Elsevier Ltd. All rights reserved.

Formato

251-255

Identificador

http://dx.doi.org/10.1016/j.foodchem.2014.01.071

Food Chemistry. Oxford: Elsevier Sci Ltd, v. 155, p. 251-255, 2014.

0308-8146

http://hdl.handle.net/11449/113456

10.1016/j.foodchem.2014.01.071

WOS:000333730000037

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Food Chemistry

Direitos

closedAccess

Palavras-Chave #Flavonoids #Antimutagenicity #Ames test
Tipo

info:eu-repo/semantics/article