Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
03/12/2014
03/12/2014
01/01/2014
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 10/17262-0 Processo FAPESP: 11/01954-2 Processo FAPESP: 10/14110-4 Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved. |
Formato |
56-66 |
Identificador |
http://dx.doi.org/10.1016/j.reprotox.2013.11.001 Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014. 0890-6238 http://hdl.handle.net/11449/112670 10.1016/j.reprotox.2013.11.001 WOS:000331028900008 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Reproductive Toxicology |
Direitos |
closedAccess |
Palavras-Chave | #Bisphenol A #Prostate #Inflammation #Indole-3-carbinol #Chemoprevention #Reproductive toxicology |
Tipo |
info:eu-repo/semantics/article |