Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework


Autoria(s): Da Rocha, Mitscheli Sanches; Arnold, Lora L.; Oliveira, Maria Luiza Cotrim Sartor de; Ihlaseh Catalano, Shadia M.; Ferragut Cardoso, Ana Paula; Pontes, Merielen G. N.; Ferrucio, Bianca; Dodmane, Puttappa R.; Cohen, Samuel Monroe; Camargo, João Lauro Viana de
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

03/12/2014

03/12/2014

01/05/2014

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Processo FAPESP: 06/60506-1

Processo FAPESP: 09/02754-7

Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.

Formato

393-406

Identificador

http://dx.doi.org/10.3109/10408444.2013.877870

Critical Reviews In Toxicology. London: Informa Healthcare, v. 44, n. 5, p. 393-406, 2014.

1040-8444

http://hdl.handle.net/11449/112305

10.3109/10408444.2013.877870

WOS:000335217800001

Idioma(s)

eng

Publicador

Informa Healthcare

Relação

Critical Reviews In Toxicology

Direitos

closedAccess

Palavras-Chave #bladder cancer #cell proliferation #cytotoxicity #diuron #metabolites #hyperplasia #urothelium
Tipo

info:eu-repo/semantics/article