Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
03/12/2014
03/12/2014
01/05/2014
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 06/60506-1 Processo FAPESP: 09/02754-7 Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance. |
Formato |
393-406 |
Identificador |
http://dx.doi.org/10.3109/10408444.2013.877870 Critical Reviews In Toxicology. London: Informa Healthcare, v. 44, n. 5, p. 393-406, 2014. 1040-8444 http://hdl.handle.net/11449/112305 10.3109/10408444.2013.877870 WOS:000335217800001 |
Idioma(s) |
eng |
Publicador |
Informa Healthcare |
Relação |
Critical Reviews In Toxicology |
Direitos |
closedAccess |
Palavras-Chave | #bladder cancer #cell proliferation #cytotoxicity #diuron #metabolites #hyperplasia #urothelium |
Tipo |
info:eu-repo/semantics/article |