Worldwide HLA-E nucleotide and haplotype variability reveals a conserved gene for coding and 3 ' untranslated regions
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
03/12/2014
03/12/2014
01/02/2014
|
Resumo |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The human leukocyte antigen-E (HLA-E) locus is a human major histocompatibility complex (MHC) gene associated with immune-modulation and suppression of the immune response by the interaction with specific natural killer (NK) and T cell receptors (TCRs). It is considered one of the most conserved genes of the human MHC; however, this low nucleotide variability seems to be a consequence of the scarce number of studies focusing on this subject. In this manuscript we assessed the nucleotide variability at the HLA-E coding and 3 ' untranslated regions (3 ' UTRs) in Brazil and in the populations from the 1000Genomes Consortium. Twenty-eight variable sites arranged into 33 haplotypes were detected and most of these haplotypes (98.2%) are encoding one of the two HLA-E molecules found worldwide, E*01:01 and E*01:03. Moreover, three worldwide spread haplotypes, associated with the coding alleles E*01:01:01, E*01:03:01 and E*01:03:02, account for 85% of all HLA-E haplotypes, suggesting that they arose early before human speciation. In addition, the low nucleotide diversity found for the HLA-E coding and 3 ' UTR in worldwide populations suggests that the HLA-E gene is in fact a conserved gene, which might be a consequence of its key role in the modulation of the immune system. |
Formato |
82-93 |
Identificador |
http://dx.doi.org/10.1111/tan.12283 Tissue Antigens. Hoboken: Wiley-blackwell, v. 83, n. 2, p. 82-93, 2014. 0001-2815 http://hdl.handle.net/11449/112304 10.1111/tan.12283 WOS:000329927000003 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
Tissue Antigens |
Direitos |
closedAccess |
Palavras-Chave | #haplotypes #human leukocyte antigen-E #lineages #natural selection #variability |
Tipo |
info:eu-repo/semantics/article |