Association between IL8 haplotypes and pathogen levels in chronic periodontitis


Autoria(s): Finoti, L. S.; Corbi, S. C T; Anovazzi, G.; Teixeira, S. R L; Steffens, J. P.; Secolin, R.; Kim, Y. J.; Orrico, Silvana Regina Perez; Cirelli, Joni Augusto; Mayer, M. P A; Scarel-Caminaga, R. M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

10/05/2013

Resumo

Chronic periodontitis (CP) is considered to be a multifactorial disease influenced by microbial and genetic factors. The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/TTC haplotype is associated with subgingival levels of periodontopathogens. Sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the IL8 haplotype, were evaluated. After clinical periodontal evaluation, each group was subdivided according to the presence (CP) or absence (H) of periodontitis. Four subgingival samples were obtained from CP and two samples per subject from H patients. The levels and proportions of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were analyzed using quantitative real-time polymerase chain reaction (q-PCR). No differences were found in the proportion of periodontopathogenic bacteria between groups with the presence or absence of the IL8 haplotype. However, in the CP groups, the levels of periodontopathogens were significantly higher in the individuals without the IL8 haplotype than in the individuals with the IL8 haplotype. These results suggest that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/TTC haplotype than in patients without this haplotype. © 2013 Springer-Verlag Berlin Heidelberg.

Formato

1-8

Identificador

http://dx.doi.org/10.1007/s10096-013-1884-y

European Journal of Clinical Microbiology and Infectious Diseases, p. 1-8.

0934-9723

1435-4373

http://hdl.handle.net/11449/75378

10.1007/s10096-013-1884-y

WOS:000324493200012

2-s2.0-84877093567

Idioma(s)

eng

Relação

European Journal of Clinical Microbiology and Infectious Diseases

Direitos

closedAccess

Tipo

info:eu-repo/semantics/article