European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil


Autoria(s): Souza, Doralina Guimarães Brum; Luizon, Marcelo Rizzatti; Santos, Antônio Carlos; Lana-Peixoto, Marco Aurélio; Rocha, Cristiane Franklin; Brito, Maria Lucia; de Oliveira, Enedina Maria Lobato; Bichuetti, Denis Bernardi; Gabbai, Alberto Alan; Diniz, Denise Sisterolli; Kaimen-Maciel, Damacio Ramon; Comini-Frota, Elizabeth Regina; Vieira Wiezel, Claudia E.; Muniz, Yara Costa Netto; da Silva Costa, Roberta Martins; Mendes-Junior, Celso Teixeira; Donadi, Eduardo Antônio; Barreira, Amilton Antunes; Simões, Aguinaldo Luiz
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

20/03/2013

Resumo

Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil. © 2013 Brum et al.

Identificador

http://dx.doi.org/10.1371/journal.pone.0058925

PLoS ONE, v. 8, n. 3, 2013.

1932-6203

http://hdl.handle.net/11449/74857

10.1371/journal.pone.0058925

WOS:000317562600045

2-s2.0-84875195830

2-s2.0-84875195830.pdf

Idioma(s)

eng

Relação

PLOS ONE

Direitos

openAccess

Palavras-Chave #adult #African American #American Indian #ancestry informative marker #bone marrow #Brazil #controlled study #European American #female #gene frequency #gene insertion #genealogy #genotype #geographic distribution #high risk population #human #human tissue #indel mutation #major clinical study #male #multiple sclerosis #myelooptic neuropathy #plesiomorphy #population genetic parameters #single nucleotide polymorphism
Tipo

info:eu-repo/semantics/article