Cardiac remodeling induced by smoking: Concepts, relevance, and potential mechanisms
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
04/12/2012
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Resumo |
Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke. © 2012 Bentham Science Publishers. |
Formato |
442-447 |
Identificador |
http://dx.doi.org/10.2174/187152812803589958 Inflammation and Allergy - Drug Targets, v. 11, n. 6, p. 442-447, 2012. 1871-5281 http://hdl.handle.net/11449/74048 10.2174/187152812803589958 2-s2.0-84870257839 |
Idioma(s) |
eng |
Relação |
Inflammation and Allergy - Drug Targets |
Direitos |
closedAccess |
Palavras-Chave | #Matrix metalloproteinases #Oxidative stress #Tobacco smoke exposure #Ventricular remodeling #acetylcysteine #adenosine triphosphate #beta carotene #calcium channel L type #calcium ion #gamma interferon #gelatinase B #interleukin 1 #interleukin 18 #interleukin 6 #mitogen activated protein kinase #neurohormone #nicotine #nitric oxide #reactive oxygen metabolite #taurine #tobacco smoke #tumor necrosis factor alpha #vitamin D #calcium mobilization #cytokine production #energy metabolism #exposure #heart disease #heart infarction #heart muscle contractility #heart size #heart ventricle failure #heart ventricle hypertrophy #heart ventricle remodeling #hemodynamic stress #hypoxemia #inflammation #nonhuman #oxidative stress #renin angiotensin aldosterone system #smoking #supplementation #Animals #Humans #Inflammation #Matrix Metalloproteinases #Mitogen-Activated Protein Kinases #Nitric Oxide #Oxidative Stress #Smoking #Ventricular Dysfunction, Left #Ventricular Remodeling |
Tipo |
info:eu-repo/semantics/article |