Determination of atenolol in pharmaceutical formulations by diffuse reflectance spectroscopy
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/10/2008
|
Resumo |
A simple analytical method for quantification of atenolol in pharmaceutical formulations by diffuse reflectance spectroscopy is described. The method is based on the reaction, on the filter paper surface, between the drug and p-chloranil producing a colored compound. The best reaction conditions were obtained with 20 μL of atenolol solution and 20 μL of p-chloranil. All reflectance measurements were carried out at 550 nm and the linear range was from 1.13×10-2 to 7.88×10-2 mol L-1 (r = 0.9992). The limit of detection was 2.80 × 10-3 mol L-1. The proposed method was successfully applied to analysis of different commercial brands of pharmaceutical formulations and the results obtained by the proposed method were in good agreement with those obtained using the British Pharmacopoeia method. |
Formato |
7-12 |
Identificador |
http://dx.doi.org/10.1590/S0100-46702008000400001 Ecletica Quimica, v. 33, n. 4, p. 7-12, 2008. 0100-4670 http://hdl.handle.net/11449/70596 10.1590/S0100-46702008000400001 S0100-46702008000400001 2-s2.0-58649119855 2-s2.0-58649119855.pdf |
Idioma(s) |
eng |
Relação |
Eclética Química |
Direitos |
openAccess |
Palavras-Chave | #Atenolol #Diffuse reflectance spectroscopy #p-chloranil, pharmaceutical formulations |
Tipo |
info:eu-repo/semantics/article |