Prevenção de hemoglobinopatias a partir do estudo em gestantes


Autoria(s): Viana-Baracioli, Lígia M. S.; Bonini-Domingos, Cláudia R.; Pagliusi, Regina A.; Naoum, Paulo C.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/12/2001

Resumo

The Brazilian population, presents genes for abnormal hemoglobins with variable frequencies, which are influenced by the founding racial groups. Thus, the detection of carriers of the genetic alterations is important for public health, since they represent sources of new beterozygotes and possible homozygotes. The control of the hemoglobin pathologies has been possible by means of genetic counseling and early diagnosis. The clinical follow-up of the homozygotes and the orientation of the beterozygotes and especially the couples at risk represent a more effective mode of acting to avoid the birth of children who are carriers of a genetic disease, that is frequently lethal. For these reasons this work had as its objectives: to evaluate the importance of testing in pregnant women for the detection of hemoglobin pathologies with the purpose of investigating the prevalence, attaining prevention, a familial study and awareness; for the positive cases such as couples at risk, orient as to appropriate medical attendance; and to evaluate the response to the program. Of the total of 696 pregnant women analysed, 10.7% revealed hemoglobin pathologies with the following rates: alpha Thalassemia 6.75%; Hb AS 2.01%; beta minor Thalassemia 1.29%; Hb AC 0.28%; Hb AJ 0.14%; Hb AS/Alpha Thalassemia 0.14% and P.H.H.F. 0.14%. The high rates of hemoglobin pathologies encountered in the population of pregnant women studied shows the necessity of the implantation of tests for these abnormalities in the pre-natal routine, since in this period the mothers are more apt to be preoccupied with their own health and that of their babies and, however earlier diagnosed the alterations in the hemoglobins, better and more adequate will be the orientations given the couple.

Formato

31-39

Identificador

http://dx.doi.org/10.1590/S1516-84842001000100005

Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 31-39, 2001.

1516-8484

http://hdl.handle.net/11449/66693

10.1590/S1516-84842001000100005

S1516-84842001000100005

2-s2.0-33747336091

2-s2.0-33747336091.pdf

Idioma(s)

por

Relação

Revista Brasileira de Hematologia e Hemoterapia

Direitos

openAccess

Palavras-Chave #Abnormal hemoglobin #Hemoglobinopathies in pregnants #Thalassemia
Tipo

info:eu-repo/semantics/article