Liver HLA-G expression is associated with multiple clinical and histopathological forms of chronic hepatitis B virus infection


Autoria(s): Souto, F. J. D.; Crispim, J. C. O.; Ferreira, S. C.; da Silva, A. S. M.; Bassi, C. L.; Soares, Christiane Pienna; Zucoloto, S.; Rouas-Freiss, N.; Moreau, P.; Martinelli, A. L. C.; Donadi, E. A.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/02/2011

Resumo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As the mechanisms leading to the persistence of hepatitis B virus (HBV) infection are poorly understood and as the histocompatibility leucocyte antigen (HLA)-G is well described as a tolerogenic molecule, we evaluated HLA-G expression in 74 specimens of HBV liver biopsies and in 10 specimens obtained from previously healthy cadaver liver donors. HBV specimens were reviewed and classified by the METAVIR score, and HLA-G expression was assessed by immunohistochemistry. No HLA-G expression was observed in control hepatocytes. In contrast, 57 (77%) of 74 HBV specimens showed soluble and membrane-bound HLA-G expression in hepatocytes, biliary epithelial cells or both. No associations between the intensity of HLA-G expression and patient age or gender, HBeAg status, severity of liver fibrosis, and grade of histological findings were observed. Although significance was not reached (P = 0.180), patients exhibiting HLA-G expression presented a higher median HBV DNA viral load (105 copies/mL) than those who did not express HLA-G (103.7 copies/mL). These results indicate that HLA-G is expressed in most cases of chronic HBV infection in all stages and may play a role in the persistency of HBV infection.

Formato

102-105

Identificador

http://dx.doi.org/10.1111/j.1365-2893.2010.01286.x

Journal of Viral Hepatitis. Malden: Wiley-blackwell Publishing, Inc, v. 18, n. 2, p. 102-105, 2011.

1352-0504

http://hdl.handle.net/11449/40836

10.1111/j.1365-2893.2010.01286.x

WOS:000286257200004

Idioma(s)

eng

Publicador

Wiley-Blackwell Publishing, Inc

Relação

Journal of Viral Hepatitis

Direitos

closedAccess

Palavras-Chave #hepatitis B virus #histocompatibility leukocyte antigen #HLA antigens #immunohistochemistry #oncoviruses
Tipo

info:eu-repo/semantics/article