NOVEL EVIDENCE THAT BETA-ADRENOCEPTORS OF THE MEDIAL SEPTAL AREA REGULATE BLOOD-PRESSURE AND ELECTROLYTE BALANCE
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
15/09/1995
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Resumo |
We investigated the participation of the beta-adrenoceptors of the septal area (SA) in sodium and potassium excretion and urine flow. The alterations in arterial pressure and some renal functions were also investigated. The injection of 2.10(-9) to 16.10(-9)M of isoproterenol, through a cannula permanently implanted into the SA produced a significant dose-dependent decrease in urinary Na+ and K+ excretion and urinary flow. Pretreatment with 16.10(-9) M butoxamine antagonized the effect of 4.10(-9) M isoproterenol but pretreatment with 16.10(-9) M practolol did not abolish the effect of isoproterenol. The beta 2-agonist terbutaline and salbutamol (4.10(-9) M when injected intraseptally also caused a decrease in urine flow and in renal Na+ and K+ excretion. After injection of isoproterenol or salbutamol (4.10(-9) M) into the SA, the arterial pressure, glomerular, filtration rate (GFR) and filtered Nd were reduced while Na+ fractional reabsorption was increased. The results indicate that the beta 2-adrenoceptors of the SA play a role in the decrease of Na+, K+ and urine flow and this effect may be due to a drop in GFR and filtered Na+ and to the rise in tubular Na+ reabsorption. |
Formato |
1605-1611 |
Identificador |
http://dx.doi.org/10.1016/0024-3205(95)02136-7 Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 57, n. 17, p. 1605-1611, 1995. 0024-3205 http://hdl.handle.net/11449/37794 10.1016/0024-3205(95)02136-7 WOS:A1995RV12800007 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Life Sciences |
Direitos |
closedAccess |
Palavras-Chave | #SEPTAL AREA #ELECTROLYTE BALANCE #BLOOD PRESSURE |
Tipo |
info:eu-repo/semantics/article |